Potassium channel inhibitors and method

Details Potassium channel inhibitors and method Potassium channel inhibitors and method

A - Human Necessities

61

K

A61K 31/18 (2006.01) A61K 31/352 (2006.01) A61K 31/4709 (2006.01) C07C 311/13 (2006.01) C07C 311/20 (2006.01) C07D 215/42 (2006.01) C07D 311/68 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 491/04 (2006.01) C07D 493/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2341678

Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have structure (I) where A, B, D, Q, X1, R, R1, X2 and R2 are as defined herein. These compounds are useful as antiarrhythmic agents. In addition, a method is provided for preventing cardiac arrythmia employing the above compounds.

Les indanes, les benzopyrannes, et les analogues de ceux-ci sont des inhibiteurs de canaux potassium et des agents bloquants de Ikur, et correspondent à la structure (I), dans laquelle A, B, D, Q, X<1>, R, R<1>, X<2>, et R<2> sont tels que définis dans cette structure. Ces composés sont utiles en tant qu'agents anti-arythmisants. Cette invention concerne en outre une méthode destinée à prévenir l'arythmie cardiaque à l'aide des composés susmentionnés.

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