Potassium channel interactors and uses therefor

Details Potassium channel interactors and uses therefor Potassium channel interactors and uses therefor

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 38/17 (2006.01) A61P 25/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12P 21/02 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2351365

The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

L'invention concerne des molécules isolées d'acides nucléiques désignées "molécules d'acides nucléiques PCIP" codant pour les protéines qui lient les canaux potassiques et modulent les activités à médiation par canaux potassiques. L'invention concerne aussi des molécules d'acides nucléiques antisens, des vecteurs d'expression recombinants contenant des molécules d'acides nucléiques PCIP, des cellules hôtes dans lesquelles on a introduit des vecteurs d'expression et, enfin, des animaux transgéniques non humaines dans lesquels on a introduit ou rompu un gène PCIP. L'invention concerne en outre des protéines PCIP isolées, des protéines de fusion, des peptides antigéniques et des anticorps anti-PCIP. Elle concerne enfin des procédés diagnostiques utilisant les compositions de l'invention.

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