C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/04 (2006.01) A61K 31/517 (2006.01)
Patent
CA 2601527
This invention relates to novel potassium channel modulating agents, and their use in the preparation of pharmaceutical compositions. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels, in particular respiratory diseases, epilepsy, convulsions, vascular spasms, coronary artery spasms, renal disorders, polycystic kidney disease, bladder spasms, urinary incontinence, bladder outflow obstruction, irritable bowel syndrome, gastrointestinal dysfunction, secretory diarrhoea, ischaemia, cerebral ischaemia, ischaemic heart disease, angina pectoris, coronary heart disease, traumatic brain injury, psychosis, schizophrenia, anxiety, depression, dementia, memory and attention deficits, Alzheimer's disease, dysmenorrhea, narcolepsy, Reynaud's disease, intermittent claudication, Sjorgren's syndrome, migraine, arrhythmia, hypertension, absence seizures, myotonic muscle dystrophia, xerostomi, diabetes type II, hyperinsulinemia, premature labour, baldness, cancer, immune suppression or pain.
L~invention concerne les nouveaux agents modulateurs du canal potassique et leur utilisation dans la préparation de compositions pharmaceutiques. De plus, l~invention concerne les compositions pharmaceutiques nécessaires au traitement ou à l~atténuation de maladies ou troubles associés à l~activité des canaux potassiques, en particulier les maladies respiratoires, l~épilepsie, les convulsions, les angiospasmes, les spasmes coronariens, les troubles rénaux, la maladie polykystique des reins, les spasmes de la vessie, l~incontinence urinaire, l~obstruction de l~évacuation de la vessie, le syndrome du colon irritable, la dysfonction gastro-intestinale, les diarrhées sécrétoires, l~ischémie, l~ischémie cérébrale, la maladie ischémique du cAEur, l~angine de poitrine, la maladie coronarienne du cAEur, la lésion cérébrale traumatique, la psychose, la schizophrénie, l~anxiété, la dépression, la démence, les déficiences de la mémoire et de l~attention, la maladie d~Alzheimer, l~algoménorrhée, la narcolepsie, la maladie de Reynaud, la claudication intermittente, le syndrome de Sjögren, la migraine, l~arythmie cardiaque, l~hypertension, l~absence, la dystrophie myotonique, la xérostomie, les diabètes de type II, l~hyperinsulinisme, le travail prématuré, la calvitie, le cancer, l~immuno-suppression ou la douleur.
Eriksen Birgitte L.
Hougaard Charlotte
Soerensen Ulrik Svane
Teuber Lene
Mccarthy Tetrault Llp
Neurosearch A/s
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