Potassium channel opener

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/19 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 11/00 (2006.01) A61P 13/10 (2006.01) A61P 25/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2445330

A potassium channel opener which contains as the active ingredient a compound (e.g., pimaric acid) represented by the formula (I): (I) wherein R1 to R7 each represents alkyl, alkenyl, halogeno, hydroxy, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxy, aryl, acyl, carboxyl, alkoxycarbonyl, a hydroxamate group, sulfo, carbamoyl, or a sulfonamide, aldehyde, or nitrile group, provided that R4 and R6 may be bonded to R5 and R7, respectively, to form a ring; and the three bonds each indicated by ---- each is a single bond or one of these is a double bond and the others are single bonds.

La présente invention se rapporte à un agent d'ouverture du canal potassique qui contient en tant que principe actif un composé (par exemple, de l'acide pimarique) représenté par la formule (I) dans laquelle R?1¿ à R?7¿ représentent chacun alkyle, alcényle, halogéno, hydroxy, haloalkyle, hydroxyalkyle, aminoalkyle, alcoxy, aryle, acyle, carboxyle, alcoxycarbonyle, un groupe hydroxamate, sulfo, carbamoyle, ou un sulfonamide, aldéhyde, ou un groupe nitrile, à condition que R?4¿ et R?6¿ puissent être à liés R?5¿ et R?7¿, respectivement, de manière à former un cycle ; et les trois liaisons représentées chacune par <u>----</u> sont chacune une liaison simple ou bien l'une d'elles est une liaison double et les autres sont des liaisons simples.

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