C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) G01N 33/53 (2006.01) G01N 33/567 (2006.01)
Patent
CA 2337835
The present invention provides novel, isolated potassium channel subunits and polynucleotides which identify and encode such subunits. The invention also provides expression vectors and host cells comprising nucleic acid sequences encoding such potassium channels. The invention also provides antibodies directed to the potassium channels and methods of diagnosing and treating diseases associated with activity of such potassium channels. In addition, the invention provides screening assays employing the polypeptide, nucleotide, and antibody compositions, and agonist and antagonist compounds selected by such screening assays.
L'invention concerne de nouvelles sous-unités isolées de canaux K et des polynucléotides qui identifient et codent ces sous-unités. L'invention concerne également des vecteurs d'expression et des cellules hôtes comprenant des séquences d'acides nucléiques codant pour ces canaux K. Elle concerne ensuite des anticorps dirigés sur ces canaux K et des procédés pour diagnostiquer et traiter les maladies associées à l'activité de ces canaux K. En outre, l'invention concerne des dosages de criblage utilisant des compositions de polypeptides, de nucléotides et d'anticorps, de même que des composés agonistes et antagonistes sélectionnés au moyen de ces dosages de criblage.
Chavez Raymond A.
Forsayeth John R.
Zhao Byron B.
Elan Pharmaceuticals Inc.
Gowling Lafleur Henderson Llp
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