Potassium salt of (s)-omeprazole

Details Potassium salt of (s)-omeprazole Potassium salt of (s)-omeprazole

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4439 (2006.01) A61P 1/00 (2006.01)

Patent

CA 2357744

The present invention relates to a novel form of 5-methoxy-2-[[(4-methoxy-3,5- dimethyl-2-pyridinyl)methyl]sulfinyl]-1H--benzimidazole, known under the generic name omeprazole. More specifically, it relates to a novel crystalline form of the potassium salt of the (S)- enantiomer of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2- pyridinyl)methyl]sulfinyl]-1H-benzimidazole. The present invention also relates to processes for preparing such a form of the potassium salt of (S)- omeprazole and pharmaceutical compositions containing it.

L'invention concerne une nouvelle forme de 5-méthoxy-2-[[(4-méthoxy-3,5-diméthyl-2-pyridinyl)-méthyl]sulfinyl]-1<u>H</u>-benzimidazole, connue sous le nom générique d'oméprazole. L'invention porte notamment sur une nouvelle forme cristalline du sel de potassium du (S)-énantiomère de 5-méthoxy-2-[[(4-méthoxy-3,5-diméthyl-2-pyridinyl)méthyl]sulfinyl]-1<u>H</u>-benzimidazole. L'invention se rapporte encore aux procédés de préparation de ladite forme de sel de potassium de (S)-oméprazole et à des compositions pharmaceutiques les contenant.

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