Potent and selective inhibition by aurintricarboxylic acid

Details Potent and selective inhibition by aurintricarboxylic acid Potent and selective inhibition by aurintricarboxylic acid

C - Chemistry, Metallurgy

12

Q

C12Q 1/70 (2006.01) A61K 31/194 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2570158

The severe acute respiratory syndrome virus (SARS) is a coronavirus that instigated regional epidemics in Canada and several Asian countries in 2003. The newly identified SARS coronavirus (SARS-CoV) can be transmitted among humans and cause severe or even fatal illnesses. As preventive vaccine development takes years to complete and adverse reactions have been reported to some veterinary coronaviral vaccines, anti-viral compounds must be relentlessly pursued. In this study, we analyzed the effect of aurintricarboxylic acid (ATA) on SARS-CoV replication in cell culture, and found that ATA could drastically inhibit SARS-CoV replication, with viral production being more than 1000 fold than that in the untreated control. ATA is also shown to be an effective anti-viral for several other viruses, including West Nile Virus and variola virus.

Le virus du syndrome respiratoire sévère aigu (SARS) est un coronavirus qui a favorisé des épidémies régionales au Canada et dans plusieurs pays asiatiques en 2003. Le coronavirus nouvellement identifié SARS (SARS-CoV) peut être transmis aux humains et provoquer des maladies sévères voire même mortelles. Alors que le développement d'un vaccin préventif prend des années et que des réactions indésirables ont été signalées pour quelques vaccins coronaviraux vétérinaires, des composés anti-viraux doivent être recherchés inlassablement. Dans une étude, nous avons analysé l'effet de l'acide aurine- tricarboxylique (ATA) sur la reproduction du SARS-CoV dans une culture de cellules, et nous avons trouvé que l'ATA pouvait inhiber efficacement la reproduction du SARS-CoV, avec un production virale de plus de 1000 fois que ce qu'on observe dans le contrôle non traité. ATA s'avère être un anti-viral efficace pour plusieurs autres virus, y compris le virus du West Nile et le virus de la variole.

Affiliated with

Also associated with

Rating

Potent and selective inhibition by aurintricarboxylic acid does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Potent and selective inhibition by aurintricarboxylic acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Potent and selective inhibition by aurintricarboxylic acid will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1803316