Potent conjugates and hydrophilic linkers

Details Potent conjugates and hydrophilic linkers Potent conjugates and hydrophilic linkers

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2722109

Linkers for binding drugs to cell binding agents are modified to hydrophilic linkers by incorporating a polyethylene glycol spacer. The potency or the efficacy of the cell-binding agent-drug conjugates is surprisingly enhanced several folds in a variety of cancer cell types, including those expressing a low number of antigens on the cell surface or cancer cells that are resistant to treatment.

L'invention concerne des coupleurs pour lier des médicaments à des agents de liaison de cellule modifiés en coupleurs hydrophiles par incorporation d'un espaceur de polyéthylèneglycol. La puissance ou l'efficacité des conjugués d'agent de liaison à une cellule-médicament est renforcée de manière surprenante plusieurs fois dans divers types de cellules cancéreuses, y compris celles exprimant un faible nombre d'antigènes sur la surface cellulaire ou les cellules de cancer qui sont résistantes à un traitement.

Affiliated with

Also associated with

Rating

Potent conjugates and hydrophilic linkers does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Potent conjugates and hydrophilic linkers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Potent conjugates and hydrophilic linkers will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2084313