Potent inhibitor of hcv serine protease

Details Potent inhibitor of hcv serine protease Potent inhibitor of hcv serine protease

A - Human Necessities

61

K

A61K 31/4709 (2006.01) A61K 9/00 (2006.01) A61K 38/05 (2006.01) A61K 38/12 (2006.01) A61K 45/06 (2006.01) A61P 31/14 (2006.01)

Patent

CA 2500259

Disclosed are oral pharmaceutical compositions, kits and methods of treating and preventing Hepatitis C Viral (HCV) infections wherein Compound (1), a potent inhibitor of HCV serine protease, or a pharmaceutically acceptable salt thereof, is administered in a selected dosage range: Formula (1) Also disclosed are the use of a compound of formula (1), or a pharmaceutically acceptable salt thereof, as a control substance for validating an HCV replication assay and also as a control substance for determining the relative effectiveness of one or more substances, alone or in combination, to inhibit the replication of HCV.

L'invention concerne des compositions pharmaceutiques orales, des trousses et des méthodes de traitement et de prévention d'infections dues au virus de l'hépatite C (VHC). Dans ces compositions, le composé de formule (1), un inhibiteur puissant de la serine protéase du VHC, ou un sel pharmaceutiquement acceptable de celui-ci, est administré dans une plage de dosage sélectionnée. L'invention concerne également l'utilisation d'un composé de formule (1), ou d'un sel pharmaceutiquement acceptable de celui-ci, en tant que substance témoin permettant de valider un test de réplication du VHC, et également en tant que substance témoin permettant de déterminer l'efficacité relative d'une ou de plusieurs substances, seules ou en combinaison, pour inhiber la réplication du VHC.

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