Potent oncolytic herpes simplex virus for cancer therapy

Details Potent oncolytic herpes simplex virus for cancer therapy Potent oncolytic herpes simplex virus for cancer therapy

C - Chemistry, Metallurgy

12

N

C12N 15/869 (2006.01) A61K 35/76 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/15 (2006.01) C12N 7/01 (2006.01) C12N 15/33 (2006.01) C12N 15/38 (2006.01)

Patent

CA 2479763

The present invention is directed to an oncolytic Herpes Simplex Virus having multiple cell membrane fusion mechanisms and preferably comprising a strict late viral promoter for effective conditional replication, such as in a malignant cell. In specific embodiments, the cell membrane fusion mechanisms are either from a mutant virus generated through random mutagenesis or through insertion of a fusogenic membrane glycoprotein, and in further specific embodiments the strict late viral promoter UL38p regulates expression of the glycoprotein.

L'invention concerne un virus herpès simplex oncolytique présentant plusieurs mécanismes de fusion de membrane cellulaire, et de préférence comprenant un promoteur viral tardif strict pour une réplication conditionnelle efficace, notamment dans une cellule maligne. Dans des modes de réalisation spécifiques, les mécanismes de fusion de membrane cellulaire sont soit générés à partir d'un virus mutant, par le biais d'une mutagenèse aléatoire, ou par le biais de l'introduction d'une glycoprotéine de membrane fusogénique, et dans d'autres modes de réalisation spécifiques, le promoteur viral tardif strict UL38p permet de réguler l'expression de cette glycoprotéine.

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