C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/18 (2006.01) A61K 31/16 (2006.01) A61K 45/00 (2006.01) A61L 2/16 (2006.01) A61P 31/10 (2006.01) C12N 15/63 (2006.01) C12N 9/78 (2006.01) C12N 15/55 (2006.01) C12N 15/79 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2660163
The invention provides methods and models for understanding how HDAC inhibitors interact with antifungal azole compounds to potentiate the activity of such compounds, using fungal strains which have selective knockouts of fungal HDAC genes. The invention further provides methods for testing antifungal agents for potential synergy with fungal HDAC inhibitors, and thus provides antifungal compound which are identified according to the methods of the invention, and methods for treatment of fungal infections using such compounds.
L'invention concerne des procédés et des modèles destinés à comprendre comment les inhibiteurs d'HDAC interagissent avec les composés d'azole antifongiques pour potentialiser l'activité de ces composés, en utilisant des souches fongiques qui comportent des inactivations sélectives de gènes HDAC fongiques. L'invention concerne en outre des procédés pour tester des agents antifongiques en vue de la synergie potentielle avec des inhibiteurs d'HDAC fongiques, et concerne donc les composés antifongiques qui sont identifiés selon les procédés de l'invention, et les procédés de traitement des infections fongiques utilisant ces composés.
Dakou Nafsika
Hu Wenqi
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Methylgene Inc.
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