Potentiation of antimicrobial effects

A - Human Necessities – 61 – K

Patent

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A61K 31/56 (2006.01) A01N 37/02 (2006.01) A01N 37/12 (2006.01) A01N 37/36 (2006.01) A01N 43/50 (2006.01) A01N 47/28 (2006.01) A61K 31/23 (2006.01) A61K 31/415 (2006.01) A61K 31/575 (2006.01) A61K 7/40 (1990.01)

Patent

CA 2118114

An antimicrobial composition comprising an antimicrobially effective amount of a combination of: A) a monoglyceride of lauric acid, a monoglyceride of monomyristic acid or a mixture of these monoglycerides, and B) at least one chemical substance selected from the following group: i) local anaesthetics of the amide type; ii) carbamide; iii) antibacterial substances in the form of steroid antibiotics, imidazole derivatives or nitroimidazole derivatives, and iv) diols with 3 - 6 carbon atoms, and C) optionally, a conventional physiologically acceptable carrier and/or physiologically acceptable additives. A process for the preparation of this composition by heating (A) to the transition temperature of the lipid, adding (B), and optionally (C), and cooling the mixture to form a solid lipid crystal composition. Use of the composition for the preparation of a dermatological preparation for combat- ting bacteria and fungi or as a preservative additive in a cosmetic product, a food product, or a medical product.

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