Potentiation of stem cell homing and treatment of organ...

Details Potentiation of stem cell homing and treatment of organ... Potentiation of stem cell homing and treatment of organ...

A - Human Necessities

61

K

A61K 35/12 (2006.01) A61K 31/40 (2006.01) A61K 31/4985 (2006.01) A61K 38/06 (2006.01) A61K 38/19 (2006.01)

Patent

CA 2677214

The invention provides methods and compositions for the treatment of multi-organ failure or kidney dysfunction, such as acute renal failure, by mesenchymal stem cells and a CD26 inhibitor, where inhibition of CD26 increases homing of the mesenchymal stem cells to a target tissue.

L'invention concerne des procédés et des compositions permettant le traitement d'une insuffisance multi-viscérale ou d'un dysfonctionnement du foie, tel qu'une insuffisance rénale aiguë, par des cellules souches mésenchymateuses et un inhibiteur du CD26, où l'inhibition du CD26 accroît l'implantation des cellules souches mésenchymateuses sur un tissu cible.

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