Potentiation of the immune response through delivery of...

A - Human Necessities – 61 – K

Patent

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A61K 38/55 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2289125

A method for stimulating proliferation of T-cells containing cytoplasmic post- prolyl dipeptidase activity; the method, in one aspect, involves contacting the T-cells with an organic compound at a concentration below 10-8M, wherein the compound is characterized in that: (a) it is capable of crossing the membrane of T-cells to enter the cytoplasm, (b) it binds to the dipeptidase activity at a concentration of below 10-8M, and thus (c) stimulates proliferation of the T-cells at that concentration.

L'invention porte sur un procédé de simulation de la prolifération de cellules T à activité cytoplasmique post-prolyle de la dipeptidase. Dans l'une de ses réalisations, le procédé consiste à mettre en contact les cellules T avec un composé organique à une concentration inférieure à 10?-8¿M, ledit composé se caractérisant: (a) par sa capacité à traverser la membrane des cellules T pour entrer dans le cytoplasme; (b) sa fixation sur l'activité de la dipeptidase à une concentration inférieure à 10?-8¿M; et (c) de ce fait, sa stimulation de la prolifération des cellules T à ladite concentration.

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