C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/18 (2006.01) A61K 31/43 (2006.01) A61K 31/47 (2006.01) A61K 31/565 (2006.01) A61K 31/65 (2006.01) A61K 38/14 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2212464
Methods for screening for compounds which potentiate the activity of antibacterial agents against bacteria resistant to the antibacterial agent alone, pharmaceutical compositions including such potentiators, and methods of treating bacterial infections using a combination of a potentiator and a potentiated antibacterial agent, which are useful for overcoming the resistance of a bacterial strain for an antibacterial agent.
Cette invention concerne des procédés de criblage de composés, lesquels sont capables de potentialiser l'activité d'agents antibactériens contre des bactéries résistant à l'agent antibactérien seul. Cette invention concerne également des compositions pharmaceutiques contenant de tels agents de potentialisation, ainsi que des méthodes de traitement d'infections bactériennes à l'aide d'une combinaison d'un agent de potentialisation et d'un agent antibactérien potentialisé. Ces compositions permettent de vaincre la résistance d'une souche bactérienne envers un agent antibactérien.
Boggs Amy
Hecker Scott
Trias Joaquim
Microcide Pharmaceuticals Inc.
Smart & Biggar
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