Powdered compositions of sensitive active materials in an at...

Details Powdered compositions of sensitive active materials in an at... Powdered compositions of sensitive active materials in an at...

A - Human Necessities

61

K

A61K 9/19 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 47/00 (2006.01) A61K 47/10 (2006.01) A61K 47/36 (2006.01) A61K 47/42 (2006.01)

Patent

CA 2557876

The invention provides a powdered formulation which is a freeze-dried mixture of a sensitive active material and an excipient containing: 0.1 - 50 % by wt of the sensitive active material, 50 - 99.99 % by wt of the excipient, wherein at least 0.1 % by wt of the mixture is an amorphous state; the formulation has a substantially reduced hygroscopicity.

L'invention concerne une préparation en poudre sous la forme d'un mélange lyophilisé d'une matière active sensible et d'un excipient. Cette préparation comprend entre 0,1 et 50 % en poids de la matière active sensible et entre 50 et 99,99 % en poids de l'excipient, au moins 0,1 % en poids de ce mélange étant dans un état amorphe. Ladite préparation présente une hygroscopicité sensiblement réduite.

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