Powdered mannitol and the procedure for preparing it

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 31/26 (2006.01) A23L 1/052 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 47/26 (2006.01) C07C 29/76 (2006.01)

Patent

CA 2342121

The present invention concerns pulverulent mannitol characterized in that it has an average diameter of between 60 and 200 m, preferably of between 80 and 180 m, a packed density, determined according to a Test A, of between 0.65 and 0.85 g/ml, preferably of between 0.7 and 0.8 g/ml and a flow factor of at least 60, preferably of between 60 and 90. The invention also concerns a process for obtaining and using the said pulverulent mannitol as an excipient in preparations intended in particular for the pharmaceutical field, and especially as a powder for filling capsules.

La présente invention est relative à un mannitol pulvérulent caractérisé en ce qu'il présente un diamètre moyen compris entre 60 et 200 µm, de préférence compris entre 80 et 180 µm, une densité tassée, déterminée selon un test A, comprise entre 0,65 et 0,85 g/ml, de préférence comprise entre 0,7 et 0,8 g/ml, une note d'écoulement d'au moins 60, de préférence comprise entre 60 et 90. L'invention concerne également son procédé d'obtention et l'utilisation dudit mannitol pulvérulent comme excipient dans des compositions destinées en particulier au domaine pharmaceutique, et notamment pour poudre de remplissage de gélules.

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