A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/275 (2006.01) A61K 9/19 (2006.01) A61K 47/18 (2006.01) A61K 47/26 (2006.01) A61K 47/32 (2006.01) A61K 47/36 (2006.01) A61K 9/00 (2006.01)
Patent
CA 2467365
The present invention relates to a formulation, in particular an aqueous formulation comprising (i) a poxvirus of one of the genera orthopoxvirus, avipoxvirus, parapoxvirus, capripoxvirus and suipoxvirus, (ii) a disaccharide, (iii) a pharmaceutically acceptable polymer and optionally (iv) a buffer. The aqueous formulation is particularly suitable for freeze drying processes resulting in a stable, freeze-dried, poxvirus containing composition. The invention further concerns a method for preparing a freeze-dried, poxvirus containing composition and the thus obtained product.
La présente invention concerne une préparation, et notamment une préparation aqueuse, comprenant (i) un poxvirus choisi parmi les genres orthopoxvirus, avipoxvirus, parapoxvirus, capripoxvirus et suipoxvirus, (ii) un disaccharide, (iii) un polymère pharmaceutiquement acceptable, et éventuellement (iv) un tampon. Cette préparation aqueuse convient particulièrement à des procédés de lyophilisation et permet d'obtenir une composition lyophilisée stable contenant un poxvirus. L'invention concerne en outre un procédé de préparation d'une composition lyophilisée contenant un poxvirus ainsi que le produit résultant.
Heller Karl
Howley Paul
Rathe Ingmar
Bavarian Nordic A/s
Smart & Biggar
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