C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 235/30 (2006.01) A61K 31/4184 (2006.01) A61K 31/423 (2006.01) A61K 31/424 (2006.01) A61K 31/428 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 29/00 (2006.01) C07D 263/58 (2006.01) C07D 277/82 (2006.01) C07D 413/12 (2006.01) C07D 498/04 (2006.01)
Patent
CA 2535749
A compound represented by the following formula (1): (see formula 1) (wherein each of R1 and R2, which may be identical to or different from each other, represents a hydrogen atom, a methyl group, or an ethyl group; each of R3a, R3b, R4a, and R4b, which may be identical to or different from each other, represents a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, a C1-4 alkyl group, a trifluoromethyl group, a C1-4 alkoxy group, a C1-4 alkylcarbonyloxy group, a di-C1-4 alkylamino group, a C1-4 alkylsulfonyloxy group, a C1-4 alkylsulfonyl group, a C1-4 alkylsulfinyl group, or a C1-4 alkylthio group, or R3a and R3b, or R4a and R4b may be linked together to form an alkylenedioxy group; X represents an oxygen atom, a sulfur atom, or N-R5 (R5 represents a hydrogen atom, a C1-4 alkyl group, a C1-4 alkylsulfonyl group, or a C1-4 alkyloxycarbonyl group); Y represents an oxygen atom, S(O)1 (1 is a number of 0 to 2), a carbonyl group, a carbonylamino group, an aminocarbonyl group, a sulfonylamino group, or an aminosulfonyl group; Z represents CH or N; n is a number of 1 to 6; and m is a number of 2 to 6) or a salt thereof; and therapeutic drugs containing any of such a compound or salt.
La présente invention a trait à un composé pour l'activation sélective du récepteur PPAR-.alpha. de formule générale (1), dans laquelle : R¿1? et R¿2?, identiques ou différents, représentent des atomes d'hydrogène ou analogues ; R¿3a?, R¿3b?, R¿4a? et R¿4b?, identiques ou différents, représentent des atomes d'hydrogène ou analogues ; X représente un atome d'oxygène ou analogue ; Y représente un atome d'oxygène, un groupe S(O)¿1? (1 est un nombre de 0 à 2), un groupe carbonyle, un groupe carbonylamino, un groupe aminocarbonyle, un groupe sulfonylamino, un groupe aminosulfonyle ou un groupe NH ; Z représente CH ou analogue ; n est un nombre de 1 à 6 ; et m est un nombre de 2 à 6 ; ou un sel dudit composé. L'invention a également trait à une composition pharmaceutique contenant un tel composé.
Abe Kazutoyo
Araki Takaaki
Nishikawa Masahiro
Oda Soichi
Okuda Ayumu
Kowa Co. Ltd.
Smart & Biggar
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