Ppar agonists

Details Ppar agonists Ppar agonists

C - Chemistry, Metallurgy

07

C

C07C 275/34 (2006.01) A61K 31/00 (2006.01) A61K 45/06 (2006.01) A61P 9/10 (2006.01) C07C 233/51 (2006.01) C07C 233/87 (2006.01) C07C 271/22 (2006.01) C07C 275/28 (2006.01) C07C 275/30 (2006.01) C07C 311/55 (2006.01) C07C 323/52 (2006.01)

Patent

CA 2438551

PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certan plasma lipid levels, including high density liporprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans.

L'invention concerne des activateurs du PPAR-alpha, et des compositions pharmaceutiques contenant ces composés. En outre, l'invention traite de l'utilisation de ces composés pour élever certains taux de lipides plasmatiques, y compris le cholestérol à lipoprotéines haute densité et pour abaisser certains autres taux de lipides plasmatiques, comme le cholestérol LDL et les triglycérides. L'invention permet, en conséquence, de traiter des maladies qui sont exacerbées par les faibles niveaux de cholestérol HDL et/ou les taux élevés de cholestérol LDL et de triglycérides, comme l'athérosclérose et les maladies cardiovasculaires chez le mammifère, y compris chez l'homme.

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