Ppar-delta ligands and methods of their use

Details Ppar-delta ligands and methods of their use Ppar-delta ligands and methods of their use

A - Human Necessities

61

K

A61K 31/194 (2006.01) A61K 31/403 (2006.01) A61K 31/426 (2006.01) A61K 31/5415 (2006.01) C07C 323/20 (2006.01) C07C 323/62 (2006.01) C07D 209/86 (2006.01) C07D 277/26 (2006.01) C07D 279/26 (2006.01)

Patent

CA 2708391

The disclosure provides compounds, compositions, and methods for modulating PPAR.delta. receptor. In one embodiment, the compounds of the disclosure comprise a tri-substituted thiazole group. The substituent at the 2-position of the thiazole group provides steric bulk to the compounds. The compounds, compositions, and methods may be useful, for example, in the treatment of cancer.

La présente invention concerne des composés, des compositions et des procédés de modulation du récepteur PPARd. Dans un mode de réalisation, les composés de la description comprennent un groupe thiazole trisubstitué. Le substituant en position 2 du groupe thiazole procure l'encombrement stérique aux composés. Les composés, les compositions et les procédés peuvent être utiles, par exemple, dans le traitement du cancer.

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