Ppar-gamma agonists for improvement of cognitive function in...

Details Ppar-gamma agonists for improvement of cognitive function in... Ppar-gamma agonists for improvement of cognitive function in...

A - Human Necessities

61

K

A61K 31/4439 (2006.01) A61K 31/445 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2623210

A method for improving cognitive function in a subject suffering from or susceptible to MCI, Alzheimer's disease or other dementias, which subject is not homozygous for the APOE4 allele, comprising the steps of: (i) screening the subject to determine that the subject is not homozygous for the APOE4 allele; and then (ii) administering a safe and effective amount of a PPAR- gamma agonist to said subject.

L'invention concerne un procédé permettant d'améliorer la fonction cognitive d'un patient souffrant ou susceptible de souffrir de déficience cognitive légère (DCL), de la maladie d'Alzheimer ou d'autres démences, ledit patient n'étant pas homozygote pour l'allèle APOE4, qui consiste: (i) à cribler le patient pour déterminer qu'il n'est pas homozygote pour l'allèle APOE4; et, ensuite, (ii) à administrer audit patient une dose sûre et efficace d'un agoniste PPAR-gamma.

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