Practical synthesis of 2'-deoxynucleosides and...

C - Chemistry – Metallurgy – 07 – H

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C07H 19/073 (2006.01) C07D 405/04 (2006.01) C07H 19/06 (2006.01) C07H 19/16 (2006.01) C07H 19/173 (2006.01)

Patent

CA 2074184

2074184 9110670 PCTABS00006 A method for the preparation of 2'-deoxynucleosides and 2',3'-dideoxy-2',3'-didehydronucleosides that includes the step of reacting a nucleoside having hydroxyl groups in the 2' and 3' positions with a mixture of acyl bromide or chloride and HX, wherein X is Br or Cl, at moderate temperature, to give a haloacyl nucleoside derivative that can be deprotected and reduced to form the desired compound.

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