Pravastatin pharmaceutical formulations and methods of their...

A - Human Necessities – 61 – K

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A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 9/28 (2006.01) A61K 31/22 (2006.01) A61K 31/225 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2473106

The present invention relates to formulations comprising a therapeutically effective amount of pravastatin, or a pharmaceutically acceptable salt thereof, and methods of their use. The present formulations and methods are designed to release little or no pravastatin in the stomach but release a therapeutic amount of pravastatin in the small intestine, thereby limiting systemic exposure of the body to pravastatin and maximizing hepatics-specific absorption of the drug. The formulations and methods of the present invention are particularly useful for treating and/or preventing conditions that are benefited by decreasing levels of lipids and/or cholesterol in the body.

L'invention concerne des préparations comprenant une quantité efficace au niveau thérapeutique de pravastatine, ou d'un sel pharmaceutiquement acceptable de celle-ci, ainsi que des procédés d'utilisation de ces préparations. Ces préparations et ces procédés sont conçus pour ne libérer que peu ou pas de pravastatine dans l'estomac, et pour libérer une quantité thérapeutique de pravastatine dans le petit intestin, ce qui permet de limiter l'exposition systémique du corps à la pravastatine et de maximiser l'absorption spécifique hépatique du médicament. Les préparations et les procédés de cette invention sont particulièrement utiles pour traiter et/ou prévenir des conditions pathologiques pour lesquelles une diminution des niveaux de lipides et/ou du cholestérol dans le corps est bénéfique.

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