C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 69/73 (2006.01) A61K 31/22 (2006.01) A61K 31/225 (2006.01) A61K 31/365 (2006.01) C07C 67/52 (2006.01) C07D 309/38 (2006.01) C12P 7/62 (2006.01)
Patent
CA 2422744
The present invention provides pravastatin sodium substantially free of pravastatin lactone and epiprava, the C-6 epimer of pravastatin. The present invention further provides a novel process for recovering pravastatin sodium from a fermentation broth in such high purity. The process includes the stages of forming an solution of the compound by extraction, obtaining an ammonium salt of pravastatin from the solution, purifying the ammonium salt of the compound and transposing the salt of the compound to pravastatin sodium.
L'invention concerne de la pravastatine sel de sodium ne contenant sensiblement pas de lactone de pravastatine sous forme lactone ni d'épipravastatine, l'épimère en C-6 de la pravastatine. Elle concerne aussi un procédé de récupération de pravastatine sel de sodium de grande pureté à partir d'un milieu de fermentation. Le procédé consiste à former une solution du composé par extraction, à obtenir la pravastatine sous forme de sel d'ammonium à partir de la solution, à purifier le sel d'ammonium du composé et à échanger le sel du composé en sel de sodium de pravastatine.
Deak Lajos
Forgacs Ilona
Keri Vilmos
Nagyne Arvai Edit
Szabo Csaba
Bennett Jones Llp
Biogal Gyogyszergyar Rt.
Teva Gyogyszergyar Reszvenytarsasag
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