C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/130, 167/44,
C07K 17/02 (2006.01) A61K 9/127 (2006.01) A61K 47/48 (2006.01) C07K 14/02 (2006.01) C07K 16/08 (2006.01) G01N 33/576 (2006.01) A61K 39/00 (2006.01)
Patent
CA 1250100
ABSTRACT OF THE DISCLOSURE A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus. The vaccine being free of an amino acid sequence corresponding to the naturally occurring envelope proteins of hepatitis B virus and a physiologically acceptable diluent. The peptide being free or linked to a carrier. The carrier being a conventional carrier or a novel carrier including a lipid vesicle stabilized by cross-linking and having covalently bonded active sites on the outer surface thereon. Such novel carrier being useful not only to link the novel peptide containing an amino acid chain with amino acids within the pre-S gene coded region of the surface antigen of hepatitis B virus, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals. The peptides of the invention can be utilized in diagnostics for the detection of antigens and antibodies.
475940
Kent Stephen B.h.
Neurath Alexander R.
California Institute Of Technology
Macrae & Co.
New York Blood Center Inc.
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