Pre-transplant accomodated organs resistant to anti-donor...

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/395 (2006.01) A61K 35/12 (2006.01) A61K 35/34 (2006.01) A61K 39/00 (2006.01) A61K 39/40 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01) G01N 33/555 (2006.01) G01N 33/567 (2006.01)

Patent

CA 2396718

This invention includes the composition of organ grafts accommodated prior to transplantation and therefore resistant to rejection by preformed antibodies. Accommodation is achieved within the donor animal by administration of sub- lethal levels of accommodation inducing factors derived from animals sensitized to the donor.

L'invention concerne la composition de greffes d'organes préparées avant transplantation et donc capables de résister au rejet par les anticorps préformés. On réalise la préparation à l'intérieur de l'animal donneur en administrant des niveaux sub-létaux de préparation comportant des facteurs d'induction provenant d'animaux sensibilisés au donneur.

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