A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/16 (2006.01) A61K 38/36 (2006.01) A61L 26/00 (2006.01) B01D 17/02 (2006.01) B01D 21/01 (2006.01) B01D 21/26 (2006.01) C07K 14/75 (2006.01) C12Q 1/56 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2306629
Increased fibrinogen yields are obtained by adding a precipitating agent to plasma having a high platelet concentration, such as platelet rich plasma. The precipitating agent may be any of several known agents, including polyethylene glycol and ammonium sulfate. The platelet rich plasma is obtained in the preferred embodiment by subjecting plasma to "soft spin" centrifugation of about 580G. An automatic, multiple decanting and multiple-speed centrifuge is preferably used to separate anti-coagulated whole blood into the platelet rich plasma component and red blood cells. The proteins, preferably fibrinogen, FXIII, and FVIII, in the platelet rich component are precipitated, and the proteins and platelets are then concentrated by further centrifugation.
On obtient des rendements accrus d'un fibrinogène en ajoutant un agent précipitant à du plasma présentant une forte concentration de plaquettes, tel que le plasma enrichi aux plaquettes. Ledit agent précipitant peut être l'un quelconque de nombreux agents connus, y compris le polyéthylèneglycol et le sulfate d'ammonium. Dans la forme de réalisation préférée, on obtient du plasma enrichi aux plaquettes en soumettant le plasma à une centrifugation "douce" d'environ 580G. Une centrifugeuse automatique à décantage multiple et vitesse variable est utilisée, de préférence, pour séparer du sang total anticoagulé en plasma enrichi aux plaquettes et en globules rouges. Les protéines, de préférence des fibrinogènes FXIII et FVIII du plasma enrichi aux plaquettes, sont précipités et les protéines et les plaquettes sont ensuite concentrées par une nouvelle centrifugation.
Harvest Technologies Corporation
Ridout & Maybee Llp
LandOfFree
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