Precursors of silk-like materials, silk-like materials and...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) C07K 14/435 (2006.01) C08G 85/00 (2006.01) C12P 21/02 (2006.01) D01F 4/00 (2006.01)

Patent

CA 2404825

The invention provides precursors of silk-like materials, a process for producing the precursors, and silk-like materials made by using the same. Copolymers of the general formula: [(GA1)j-((GA2)k-G-Y-(GA3)1)m]n, the (GA1)j moieties of which have repeated .beta.-turn type-II structure and which bear intramolecular hydrogen bonds formed along their respective molecular axes consecutively and serve as precursors of silk-like materials. In the formula (I), G is glycine; A1 is alanine with the proviso that every third A1 may be serine; A2 and A3 are each alanine, a part of which may be replaced by valine; Y is an amino acid having an asymmetric carbon atom and being capable of imparting water solubility to the copolymers; j is 6 or above; k and l are each 0 to 5; m is 1 to 7; and n is 10 or above.

La présente invention concerne des précurseurs de matières de type soie, un procédé permettant de produire lesdits précurseurs, et des matières de type soie ainsi obtenues. Cette invention a pour objet des copolymères servant de précurseurs de matières de type soie et ayant la formule générale: [(GA?1¿)¿j?-((GA?2¿)¿k?-G-Y-(GA?3¿)¿1?)¿m?]¿n?, dans laquelle les groupes fonctionnels (GA?1¿)¿j? ont une structure de type II à retournement .beta. répétée et comprennent des liaisons hydrogène intramoléculaires formées consécutivement le long de leurs axes moléculaires respectifs. Dans ladite formule (I): G est glycine ;A?1¿ est alanine, un A?1¿ sur trois pouvant être sérine ; A?2¿ et A?3¿ sont chacun alanine, dont une partie peut être remplacée par valine ; Y est un acide aminé ayant un atome de carbone asymétrique et étant capable de donner aux copolymères une solubilité dans l'eau ; j vaut 6 ou plus ; k et l valent chacun de 0 à 5 ; m vaut de 1 à 7 ; et n vaut 10 ou plus.

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