Predicting and detecting cardiac allograft rejection

Details Predicting and detecting cardiac allograft rejection Predicting and detecting cardiac allograft rejection

G - Physics

01

N

G01N 33/74 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2233724

This invention is directed to a method of diagnosing cardiac transplant rejection within a patient comprising, obtaining a sample of a biological fluid from said patient, and determining the level of a brain natriuretic peptide (BNP) or a fragment thereof, within said sample of body fluid. The step of determining the concentration of BNP involves an assay comprising at least one antibody exhibiting affinity for said BNP or a fragment thereof, and the biological fluid comprises plasma, urine or cerebrospinal fluid. Furthermore, the antibody used within the method may comprises a polyclonal antibody, a monoclonal antibody, or a combination thereof. Preferably, the method involves obtaining at least two said samples of body fluid from said patient over a period of time and comparing the BNP levels, with an increase in BNP being indicative of an upcoming rejection episode.

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