Predicting the outcome of virus infections

Details Predicting the outcome of virus infections Predicting the outcome of virus infections

C - Chemistry, Metallurgy

12

Q

C12Q 1/70 (2006.01)

Patent

CA 2339526

The present invention provides methods of predicting those individuals likely to develop persistent infection after exposure to a virus such as the hepatitis virus, particularly the hepatitis B virus. In one embodiment, the method comprises determining whether the subject carries one or more alleles associated with altered clearance of the virus. In another embodiment, the method comprises determining whether the subject carries one or more alleles associated with altered secretion of a cytokine.

L'invention concerne des procédés permettant de prédire quels individus sont susceptibles de développer une infection persistante après avoir été exposés à un virus tels que le virus de l'hépatite, en particulier le virus de l'hépatite B. Dans un mode de mise en oeuvre, ce procédé consiste à déterminer si le sujet est porteur d'un ou de plusieurs allèles associés à une modification de la clairance du virus. Dans un autre mode de mise en oeuvre, ce procédé consiste à déterminer si le sujet est porteur d'un ou de plusieurs allèles associés à une modification de la sécrétion d'une cytokine.

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