Prediction of coronary artery disease

Details Prediction of coronary artery disease Prediction of coronary artery disease

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/04 (2006.01) C12N 15/25 (2006.01) C12P 19/34 (2006.01) C07K 14/54 (2006.01) C07K 14/545 (2006.01)

Patent

CA 2282746

Methods and assays are disclosed for predicting a patients risk for an inflammatory disorder such as coronary artery disease or related vascular disorders. The methods comprise obtaining a biological sample from a patient and determining the presence or absence of a particular allele which is linked with coronary artery disease. Detection of the allele is indicative of susceptibility to develop coronary artery disease. Kits for the detection of coronary artery disease are additionally provided, as are means for identifying additional alleles associated with coronary artery disease.

On décrit des procédés et des dosages qui permettent d'évaluer le risque qu'un patient développe une maladie inflammatoire telle que la coronaropathie ou d'autres maladies vasculaires apparentées. Les procédés consistent à obtenir un échantillon biologique d'un patient puis à déterminer la présence ou l'absence d'un allèle particulier qui est lié à la coronaropathie. La détection de cet allèle indique la propension à développer une coronaropathie. On décrit également des kits de détection de la coronaropathie ainsi que des moyens permettant d'identifier des allèles supplémentaires associés à la coronaropathie.

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