Prediction of diabetes impaired wound healing by urinary...

Details Prediction of diabetes impaired wound healing by urinary... Prediction of diabetes impaired wound healing by urinary...

G - Physics

01

N

G01N 33/84 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2366080

Wound healing is impaired in many diabetics, who suffer increased risk of chronic foot ulceration and amputation. Diabetic patient with poor healing ability were found to possess significantly lower fasting urinary nitrate levels than diabetic patients with normal healing ability or non-diabetic controls, implicating decreased endogenous nitric oxide activity as the mediator of diabetes-impaired wound healing. Methods and kits are provided for predicting the wound healing ability of diabetic patients based on the levels of nitric oxide related products such as nitrate or nitrite in urine or other specimens. Methods are also provided for treating non-wound healing diabetics and monitoring diabetic ulcer treatment.

L'invention concerne l'altération de la cicatrisation de lésions chez de nombreux diabétiques qui souffrent d'un risque accru d'ulcération chronique et d'amputation du pied. Il s'est avéré que les diabétiques dont le pouvoir de cicatrisation est faible ont des niveaux de nitrate urinaire à jeun sensiblement plus bas que chez les diabétiques au pouvoir de cicatrisation normal ou lors de contrôles non diabétiques, ce qui implique une activité d'oxyde nitrique endogène réduite en tant que médiateur de l'altération de la cicatrisation de lésions chez le diabétique. L'invention concerne des procédés et des trousses permettant de prédire le pouvoir de cicatrisation chez le diabétique en fonction des niveaux de produits relatifs à l'oxyde nitrique tels que nitrate ou nitrite présent dans l'urine ou d'autres échantillons. L'invention concerne enfin le traitement de diabétiques dont les lésions ne se cicatrisent pas et la surveillance d'ulcère diabétique.

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