Prediction of inflammatory disease associated with il-1 gene...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2291731

Methods, assays and kits are disclosed for detecting a patient's susceptibility to an inflammatory disorder such as coronary artery disease, osteoporosis, nephropathy in diabetes mellitus, alopecia areata, Graves disease, systemic lupus erythamatosus, lichen sclerosis, ulcerative colitis, diabetic retinopathy, periodontal disease, juvenile chronic arthritis particularly chronic iridocyclitis, psoriasis, insulin dependent diabetes and other diseases with an IL-1 genetic component. The methods comprise obtaining a biological sample from a patient and determining the presence or absence of a particular haplotype from the IL-1 gene cluster that is associated with an inflammatory disorder. Detection of at least one of the alleles in the haplotype indicates a susceptibility for the inflammatory disorder.

L'invention concerne des procédés, dosages et kits permettant de déceler la sensibilité d'un patient à un trouble inflammatoire tel que la coronaropathie, l'ostéoporose, la néphropathie se développant au cours d'un diabète sucré, la pelade, la maladie de Graves, le lupus érythémateux disséminé, le lichen scléreux, la recto-colite hémorragique, la rétinopathie diabétique, la parodontopathie, l'arthrite chronique juvénile et en particulier l'iridocyclite chronique, le psoriasis, le diabète insulinodépendant et d'autres maladies associées à un composant génétique particulier de l'interleukine 1 (IL-1). Ces procédés consistent à obtenir un échantillon biologique d'un patient et à déterminer la présence ou l'absence d'un haplotype particulier issu du groupe de gènes de l'IL-1 qui est associé au trouble inflammatoire. La détection d'au moins un des allèles de l'haplotype indique une sensibilité au trouble inflammatoire.

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