C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) C07H 21/00 (2006.01) C12N 15/10 (2006.01) C12N 15/12 (2006.01) C12N 15/53 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01) C40B 30/00 (2006.01) C40B 30/04 (2006.01) C40B 40/08 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2668998
The invention provides materials and methods for detecting the expression of genes encoding cytochrome p450, nuclear X receptors, phase II transferases, and solute carrier family uptake pumps. The materials include sets of primers, PCR amplicons and arrays. The methods of the invention include hybridization assays. Kits and assays for the detection of the expression of the genes are also provided by the invention. In addition, the invention provides the use of the materials and methods of the invention in drug screening assays.
L'invention concerne des matériaux et des procédés permettant de détecter l'expression de gènes codant pour le cytochrome p450, des récepteurs X nucléaires, des transférases de phase II et des pompes à absorption de la famille des supports de soluté. Les matériaux comprennent des ensembles d'amorces, des amplicons de PCR et des réseaux. Les procédés de l'invention comprennent des dosages d'hybridation. L'invention concerne également des coffrets et des dosages permettant la détection de l'expression des gènes. De plus, l'invention concerne l'utilisation des matériaux et des procédés de l'invention dans des dosages de criblage de médicament.
de Lannoy Ines
Morrison Jodi A.
Shipman Robert C.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Noab Biodiscoveries Inc.
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