Pregnancy-related enzyme activity

Details Pregnancy-related enzyme activity Pregnancy-related enzyme activity

A - Human Necessities

61

K

A61K 38/43 (2006.01) A61K 38/48 (2006.01) C12N 9/64 (2006.01) C12N 15/52 (2006.01) C12N 15/57 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2455147

This invention relates to the role of the enzyme proprotein convertase 5/6 in pregnancy, and in particular to the detection or modulation of proprotein convertase 5/6 and its isoforms in the uterus. This enzyme is useful in the control of fertility, the monitoring of early pregnancy, and for the detection of uterine receptivity. The invention also relates to methods of screening for compounds which have the ability to modulate the activity or expression of proprotein convertase 5/6, which may be useful in regulating fertility in mammals. Novel forms of proprotein convertase 5/6 are also disclosed and claimed.

L'invention concerne le rôle de l'enzyme proprotéine convertase 5/6 dans la grossesse, et en particulier la détection ou la modulation de cette enzyme et de ses isoformes dans l'utérus. Il s'agit d'une enzyme utile pour le contrôle de la fertilité, le suivi relatif au début de la grossesse, et la détection de la réceptivité utérine. L'invention concerne en outre des procédés relatifs au criblage de composés capables de moduler l'activité ou l'expression de l'enzyme considérée, pouvant être utile dans la régulation de la fertilité chez les mammifères. L'invention concerne enfin des formes nouvelles de cette protéine.

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