C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/46 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2046925
ABSTRACT At least seven genes have been identified which encode proteins generally identified as pregnancy specific protein (SP1), also known as pregnancy specific beta glycoprotein (PSBG). These genes have been found using human placental SP1 labelled cDNA in a number of mammalian species, including human, baboon, cow, sheep, goat, pig and rat, and non-mammalian species, including fish and bird. The genes are classified on the basis of their nucleotide sequence, structure, glycosylation sites, restriction enzyme mapping, and tissue of origin. Genes have been found in cells of human placenta origin (three groups); in intestinal cells; in cells of both testis and placental origin; in tissue of testis origin; and in HeLa cells. One clone encodes a SP1- like protein which is specifically found in placenta and appears to have a hydrophobic C-terminal region, indicating that it is membrane bound. These cDNAs are at least 65% homologous with some members of the immunoglobulin gene superfamily such as CEA. Methods for making and using the DNA sequences, proteins, and antibodies to the proteins are also described, particularly for diagnostic work. Immunosuppressive activity and growth promoting activities have also been demonstrated by suppression of lymphocyte proliferation and inducement of megakaryocytopoiesis, respectively.
Bereskin & Parr
Oklahoma Medical Research Foundation
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