Pregnane steroids for use in the treatment of cns disorders

A - Human Necessities – 61 – K

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A61K 31/56 (2006.01) A61K 31/57 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2468248

Steroid compounds prossessing a hydrogen donor in 3beta position, either in the form of a hydroxy- or a sulfate group, function as efficient blockers of the 3alpha-hydroxy-pregnan-steroid action and thus have utility as therapeutic substances for the prevention and/or treatment of steroid related CNS disorders. Treatment methods based on the administration of these substances are disclosed, and these substances either alone or in combination are also suggested for the manufacture of pharmaceuticals for the treatment of many specific steroid induced CNS disorders.

La présente invention se rapporte à des composés stéroïdes comportant un donneur hydrogène en positon 3bêta, soit sous forme d'un groupe hydroxy soit sous forme d'un groupe sulfate, qui s'avère être des agents bloquants efficaces de l'action des 3alpha-hydroxy-prégnane-stéroides et possèdent par conséquent une utilité en tant que substances thérapeutiques pour la prévention et/ou le traitement des troubles du système nerveux central liées aux stéroïdes. L'invention se rapporte à des méthodes de traitement fondées sur l'administration de ces substances qui peuvent également être utilisées soit seules soit en combinaison- pour la fabrication de produits pharmaceutiques destinés au traitement de nombreux troubles spécifiques du système nerveux central induits par des stéroïdes.

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