Prekallikrein depleted plasma derived albumin fraction

Details Prekallikrein depleted plasma derived albumin fraction Prekallikrein depleted plasma derived albumin fraction

A - Human Necessities

61

K

A61K 38/38 (2006.01) C07K 14/76 (2006.01)

Patent

CA 2506848

An albumin containing fraction having a reduced prekallikrein activator (PKA) content and a method of manufacturing same comprising the steps of: (a) reconstitution of paste V (Cohn fractionation) (b) performing a concentration step of the fraction obtained in step (a), (c) heating the fraction obtained in step (b) in a range of from 50 ~C to 70 ~C for a sufficient time to pasteurise the fraction, and (d) optionally filling of the obtained fraction for use.

La présente invention concerne une fraction contenant de l'albumine, qui présente une teneur réduite en activateur de prékallicréine (PKA), ainsi qu'un procédé pour produire celle-ci. Ce procédé consiste (a) à reconstruire une pâte V (fractionnement de Cohn), (b) à concentrer la fraction obtenue en (a), (c) à chauffer la fraction obtenue en (b) dans une plage de températures allant de 50 ·C à 70 ·C, pendant une période suffisante pour pasteuriser cette fraction, puis (d) à charger éventuellement la fraction obtenue afin de l'utiliser.

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