Premixed formulation of piperacillin sodium and tazobactam...

A - Human Necessities – 61 – K

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Details

A61K 31/496 (2006.01) A61K 9/08 (2006.01) A61K 31/431 (2006.01) A61K 47/12 (2006.01) A61K 47/26 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2361392

The present invention provides a premixed form of a buffered piperacillin product having a near neutral pH and capable of a shelf life of at least nine months, with freezer storage (-20 °C or lower), or a refrigerated shelf life of up to 14 days at about 5 °C. The piperacillin may additionally contain a tazobactam component to inactivate beta-lactamases that commonly cause resistance to penicillins, allowing the piperacillin component to destroy susceptible bacteria. With the addition of dextrose, the premixed composition is physiologically isosmotic.

La présente invention se rapporte à une formulation pré-mélangée d'un produit à base de pipéracilline tamponné possédant un pH pratiquement neutre et pouvant être doté d'une durée de conservation d'au moins neuf mois, la durée de conservation en congélateur (à une température inférieure ou égale à 20 DEG C) ou en réfrigérateur pouvant atteindre 14 jours à environ 5 DEG C. La pipéracilline peut également contenir un composant tazobactame pour activer les béta-lactamases qui provoquent généralement la résistance aux pénicillines, ce qui permet au composant pipéracilline de détruire les bactéries sensibles. Lorsqu'elle est additionnée de dextrose, cette composition pré-mélangée est physiologiquement isosmotique.

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