Preparation and application of total salvianolic acid

Details Preparation and application of total salvianolic acid Preparation and application of total salvianolic acid

C - Chemistry, Metallurgy

07

C

C07C 59/52 (2006.01) A61K 31/19 (2006.01) A61K 31/34 (2006.01) C07D 307/84 (2006.01)

Patent

CA 2486378

A process for preparing total salvianolic acid and the use of the product are disclosed. The process comprises: tanshin is hot-extracted with water, the extract is separated and refined by polyamide column and macroporous adsorption resin column, and lyophilized to obtain total salvianolic acid. The yield of the final end product is more than 4 percent based on the amount of crude drug and the content of total salvianolic acid is more than 80 percent. The total salvianolic acid obtained can be used as the medicine for preventing and treating cerebrovascular and cardiovascular diseases.

La présente invention concerne un processus de préparation d'acide tanshintotalphénolique et l'utilisation de ce produit. Ce processus se décompose ainsi: le tanshin est extrait à chaud avec de l'eau, cet extrait est séparé et raffiné par une colonne de polyamide et par une colonne de résine d'adsorption macroporeuse, puis il est lyophilisé de façon qu'on obtienne un acide tanshintotalphénolique. Le rendement de ce produit fini est pour 4 pour-cent la drogue brute et le contenu d'acide totalphénolique représente plus de 80 pour-cent. L'acide tanshintotalphénolique obtenu peut être utilisé comme médicament destiné à la prévention et au traitement de maladies cérébro-vasculaires et cardio-vasculaires etc..

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