Preparation and isolation of mineral acid salt of an amino...

C - Chemistry – Metallurgy – 07 – C

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260/487.7, 260/4

C07C 229/04 (2006.01) C07C 227/18 (2006.01) C07C 227/40 (2006.01) C07C 323/58 (2006.01)

Patent

CA 2006737

A cyclical process for producing and isolating a mineral acid salt of an amino acid methyl ester in high purity and yield from the reaction solution produced by esterifying an amino acid with methanol in methanol in the presence of a mineral acid, by cooling the resulting reaction solution to precipitate crystals of the mineral acid salt; filtering the crystals; drying the isolated wet crystals or washing with another organic solvent; and recycling the filtrate for reuse in the esterification reaction.

Un procédé cyclique pour produire et isoler un sel d'acide minéral d'un ester méthylique d'un acide aminé d'une pureté élevée et avec un rendement élevé à partir de la solution réactionnelle produite par estérification d'un acide aminé avec du méthanol dans du méthanol en présence d'un acide minéral, par refroidissement de la solution réactionnelle obtenue pour précipiter les cristaux du sel d'acide minéral; par filtration des cristaux; séchage des cristaux humides isolés ou lavage à l'aide d'un autre solvant organique; et recyclage du filtrat par réutilisation dans la réaction d'estérification.

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