Preparation and purification of mupirocin calcium

Details Preparation and purification of mupirocin calcium Preparation and purification of mupirocin calcium

C - Chemistry, Metallurgy

07

D

C07D 407/06 (2006.01) A61K 31/351 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2649758

The present invention relates to methods for the preparation and purification of mupirocin calcium. The process comprises adsorbing mupirocin to a hydrophobic adsorbent resin, exposing the bound mupirocin to a calcium-containing solution, washing impurities from the resin and eluting purified mupirocin calcium from the resin.

La présente invention concerne des méthodes de préparation et de purification de mupirocine calcique. Le processus consiste à adsorber la mupirocine sur une résine adsorbante hydrophobe, à exposer la mupirocine liée à une solution contenant du calcium, à éliminer les impuretés de la résine par lavage, puis à éluer la mupirocine calcique purifiée de la résine.

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