Preparation and storage of stable, antimicrobially active...

A - Human Necessities – 61 – L

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A61L 2/00 (2006.01) A61L 2/08 (2006.01) A61L 27/04 (2006.01) A61L 27/10 (2006.01) A61L 27/20 (2006.01) A61L 27/22 (2006.01) A61L 27/24 (2006.01) A61L 27/36 (2006.01) A61L 27/54 (2006.01)

Patent

CA 2646392

A method for the preparation of antimicrobially active materials is presented. The invention involves taking a base material such as allografts, xenografts, polymers, metals, and ceramics and combining it with an antimicrobially active agent, such as antibiotics, antibacterials, antifungals, antivirals, disinfectants, and polypeptides, after which it is irradiated with ionizing radiation to sterilize and stabilize the combined material. The resulting antimicrobially active material may then be stored at ambient temperature while maintaining its antimicrobial activity and the structural integrity of the base material. The invention is particularly useful for both preventing and treating a variety of infections and for increased safety in reconstructive procedures.

L'invention concerne un procédé de préparation de matières à action antimicrobienne. Cette invention consiste à prendre une matière de base telle que des allogreffes, des xénogreffes, des polymères, des métaux, et des céramiques et à les combiner avec un agent à action antimicrobienne, tel que des antibiotiques, des antibactériens, des antifongiques, des antiviraux, des désinfectants, et des polypeptides, après quoi cette matière est exposée à un rayonnement ionisant afin de stériliser et stabiliser la matière combinée. La matière à action antimicrobienne obtenue peut ensuite être stockée à température ambiante tout en conservant l'activité antimicrobienne et l'intégrité structurelle de la matière de base. L'invention est particulièrement utile à la fois dans la prévention et le traitement d'une variété d'infections et pour une sécurité accrue dans des procédures de reconstruction.

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