Preparation and use of formalin-killed...

Details Preparation and use of formalin-killed... Preparation and use of formalin-killed...

A - Human Necessities

61

K

A61K 39/108 (2006.01)

Patent

CA 2104877

Disclosed is a method of producing a vaccine composition against enteric infection caused by enterotoxigenic E, coli bacteria in humans. E. coli strains selected from different known strains each having the ability of expressing a certain type of colonization factor antigens are grown in a liquid culture medium. Finally formalin-killed E. coli strain having substantially preserved antigenic and hemagglutinating properties of said certain type of colonization factor antigens, is mixed with a pharmaceutically acceptable excipient and/or diluent. Further disclosed is a method of preventing an enteric infection caused by enterotoxigenic E. coli bacteria in humans, whereby a vaccine composition comprising inactivated E. coli strain is administered to a human being for the prevention of said infection.

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