C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/38 (2006.01) A61K 31/662 (2006.01) A61P 31/18 (2006.01) C07F 9/40 (2006.01)
Patent
CA 2336791
Preparation of phosphonoformic acid analogues containing one, two, three, or more sulfur atoms are described, with specific examples. Such compounds, not excluding cognates, derivatives, and homologues thereof, are proposed to be used directly, or as prodrugs, in treating viral infections, including but not limited to HIV, herpesviruses including HSV, EBV, VZV, CMV, HSV-6 and HSV-8 (Kaposi's sarcoma); HPV; rhinoviruses; and hepatitis-linked viruses. They are also proposed to be used in treating neoplasms, and for diagnosis and therapy of diseases of bone metabolism. The compounds of the present invention are also designed as to create novel biologically active compounds or prodrugs.
La présente invention concerne la préparation d'analogues de phosphonoformate contenant un, deux, trois atomes de soufre ou plus, et des exemples spécifiques de ces derniers. Ces composés, dans lesquels sont inclus les correspondants, les dérivés et les homologues de ceux-ci, peuvent être utilisés directement ou comme prodrogues dans le traitement d'infections virales, y compris et de manière non exhaustive, le VIH; le virus de l'herpès, y compris l'herpès simplex virus, le virus Epstein-Barr, le virus varicelle-zona, le cytomégalovirus, le HSV-6 et le HSV-8 (maladie de Kaposi); le papillomavirus; les rhinovirus; et les virus liés à l'hépatite. Les composés de l'invention peuvent également être utilisés dans le traitement des néoplasmes et dans le diagnostic et la thérapie de maladies du métabolisme osseux. Ces composés ont aussi été conçus dans le but de créer de nouveaux composés ou prodrogues bioactifs.
Li Zeng-Min
Liu Xue-Wei
Mckenna Charles E.
Smart & Biggar
The University Of Southern California
LandOfFree
Preparation and use of sulfur-containing phosphonoformate... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Preparation and use of sulfur-containing phosphonoformate..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation and use of sulfur-containing phosphonoformate... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1726752