C - Chemistry – Metallurgy – 08 – F
Patent
C - Chemistry, Metallurgy
08
F
C08F 212/36 (2006.01) B01J 20/26 (2006.01) C07F 5/02 (2006.01) C08B 3/06 (2006.01) C08B 15/06 (2006.01) C08F 8/42 (2006.01) C08F 116/06 (2006.01) C08F 120/56 (2006.01) C08F 212/08 (2006.01) C40B 50/18 (2006.01) C40B 80/00 (2006.01) C07C 229/08 (2006.01)
Patent
CA 2356455
The invention provides novel solid supports comprising dihydroxyalkyl aminoalkyl and dihydroxyalkylaminobenzyl groups, and methods for making and using them. The supports are particularly useful for immobilizing and derivatizing functionalized boronic acids for use in solid phase synthesis, such as those used in combinatorial chemistries. The compositions and methods of the invention are also useful as scavenger solid supports, e.g., in solution-phase parallel synthesis of small molecule libraries, and for use in resin-to-resin transfer reactions via phase transfer of solid supported boronic acids under both aqueous and anhydrous conditions. The methods of the invention provide convergent solid-phase synthesis of symmetrically or unsymmetrically functionalized compounds, such as biphenyl compounds. Also provided are synthesizer devices, e.g., semiautomated parallel synthesizers.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
University Of Alberta
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