Preparation and uses of los-depleted outer membrane proteins...

Details Preparation and uses of los-depleted outer membrane proteins... Preparation and uses of los-depleted outer membrane proteins...

C - Chemistry, Metallurgy

12

N

C12N 1/20 (2006.01) A61K 39/02 (2006.01) A61K 39/095 (2006.01) A61K 39/42 (2006.01) C07K 14/22 (2006.01) C12P 7/64 (2006.01) C12P 19/04 (2006.01) C12P 21/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2123355

Described herein is a method for removing toxic lipooligosaccharide (LOS) from outer membranes of Gram--negative cocci, such as Neisseria meningitidis. LOS--depleted outer membranes and LOS-depleted soluble outer membrane proteins can be prepared, which are able to elicit bactericidal antibodies against homologous strains of bacteria. Vaccines and other uses of the preparations are further described.

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