A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/30 (2006.01) A61K 9/32 (2006.01) A61K 9/36 (2006.01) A61K 9/42 (2006.01) A61K 9/50 (2006.01)
Patent
CA 2338780
A preparation capable of releasing a medicinal substance at a targeted site in the intestine, wherein the preparation dose not releases medicinal substance in endogastri at all, but can quickly release a medicinal substance when it reaches the desired site in the intestine after a certain period of time from discharge of the preparation from the stomach, and wherein a core material containing a medicinal substance is coated with a mixed film of a hydrophobic organic compound - an enteric polymer. The preparation is useful for a local therapy of inflammatory disease in the intestine such as ulcerative colitis or Crohn's disease, or an oral administrative therapy with a medicinal substance of a peptide which is apt to be decomposed chemically or enzymatically in any site except for a specific site in the intestine such as the large intestine, or with a medicinal substance whose absorption site in the intestine is limited, or the like, because a medicinal substance can be delivered selectively to a specific site in the intestine.
Préparation pouvant libérer un médicament non dans l'estomac mais rapidement au niveau d'un site ciblé dans l'intestin quand ce médicament sort de l'estomac et, après une certaine durée, atteint la position souhaitée. Cette préparation consiste en un noyau contenant un médicament et en un enrobage contenant un mélange d'un composé organique hydrophobe et d'un polymère entérique. Cette préparation permet d'administrer un médicament de façon sélective à un site spécifique de l'intestin, ce qui la rend efficace pour, par exemple, des traitements localisés de maladies inflammatoires digestives, telles que la recto-colite ulcéro-hémorragique et la maladie de Crohn, ainsi que pour l'administration orale de médicaments peptidiques censés être digérés de façon chimique ou enzymatique sauf en ce qui concerne un site spécifique de l'intestin ou de médicaments absorbés exclusivement au niveau d'un site spécifique de l'intestin.
Ishibashi Takashi
Kubo Hiroaki
Mizobe Masakazu
Yoshino Hiroyuki
Osler Hoskin & Harcourt Llp
Tanabe Seiyaku Co. Ltd.
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