Preparation for endermism containing dopamine derivative

Details Preparation for endermism containing dopamine derivative Preparation for endermism containing dopamine derivative

A - Human Necessities

61

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167/254

A61K 31/215 (2006.01) A61K 9/70 (2006.01) A61K 31/22 (2006.01) A61K 31/44 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) C07C 219/28 (2006.01) C07D 213/80 (2006.01)

Patent

CA 2031243

ABSTRACT OF THE DISCLOSURE A preparation for endermism which comprises: (A) a diacylated dopamine derivative represented by the formula (I): Image CH2CH2-NH-R2 (I) wherein R1 represents an alkyl group having 3 to 7 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, substituted or unsubstituted phenyl group or a substituted or unsubstituted nitrogen-containing heterocyclic group; and R2 represents a hydrogen atom or a lower alkyl group; or a salt thereof; and (B) one or more compounds selected from lactic acid esters, fatty acid monoglycerides and higher alcohols; optionally together with (C) an unsaturated fatty acid monohydric alcohol ester. This preparation has a sustained effect, a high skin permeability and a low skin irritatativeness.

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